The Therapy of 36 Hepatic Metastasis in Colorectal Cancer Archive ...

[Abstract]

Backgrounds : Colorectal cancer is one of the most common malignant tumor.Along with the sublimate of people life,the lengthening of human life-span,there will be more and more old patient.The attack rate and case fatality rate in our country and the whole world also have a gradually adscendent tendency.Also,the ranking of colorectal cancer in malignant tumor gradually anteriad.We have found that in the most of the patient who have got colorectal cancer ,the liver is the only or the primary metastasis. Base with the date of literature,the Liver metastasis has happened in 15%~25% patients when the colorectal cancer be found. 20%~35% metastasis can be only found in liver and 50%~70% advanced stage patients get Liver metastasis.So,to control and cure Liver metastasis in one important way to improve the survival rate of colorectal cancer patient.Know ,there are a lot of way to cure hepatic metastasis in colorectal cancer,such as operation, chemotherapy of all over the body, hepatic artery chemotherapy, microwave cure, alinjection, freezing, radiotherapy and immunotherapy.How to select the trate way is a problem that worh discuss.Objective:By the analysis of 36 colorectal cancer patient who get liver metastasis,to find out the best way to cure hepatic metastasis in colorectal cancer.Methods:36 patient who got hepatic metastasis in colorectal cancer mananged between 2002-2007 at our hospital were involved.There are 22 male and 14 female,the age between 36-79,the average age is 58.All the liver metastasizes are be found before the operation.19 have only one liver metastasis.6 are found in the left external lobe of liver,4 in the left internal lobe,9 in the right lobe.11 have more than one liver metastasis ,but all the metastasizes only be foud in the right lobe.There are also 6 have diffuse liver metastasis.The size of the liver metastasis between 1-5 cm.The position and the pathology type: 12 happened at colon transversum, 5 at ascending colon,6 at decending colon, 13 at sigmoid colon. There are 10 poorly differentiated cancer, 15 well-differentiated cancer and undifferentiated cancer. The histology of lvere metastasis and colorectal cancer are same.Divide all the patients to two groups as the different therapy way: A :cut liver metastasis(n=21); B: not cut liver metastasis (n=15) .Use x2 test,to find out if there are differents between the survival rate of two groups.result:there are no patient death in the operation.5 patient death at earlier period, 2 in A group and 3 in B group.All the survival patients are follow-up visited between 0.5-5 years.The 1 year.3 year and 5 year survival rate of A group are 76.19%?38.09%?19.04%,the date of B group are 53.33%?26.67%?0%.There are 16 have recidivation of liver metastasis,in them,5 patient have do the operation of liver again.The 1 year.3 year and 5 year survival rate of people who have do the liver operation again are 80.00%?20.00%and 0.00% .the 1 year.3 year and 5 year survival rate of people who have not do the liver again are 18.18%?0.00%?0.00%?conclusion:If the primary tumor can be radical excisied, the radical excision of Liver metastasi is the best way of therapy and can obviously improved the survival rate.If the liver metastasis has recidivated,the best way of the therapy is to do a liver radical excision.

Title: The Therapy of 36 Hepatic Metastasis in Colorectal Cancer

Category: Wilms Tumor

Filename: The Therapy of 36 Hepatic Metastasis in Colorectal Cancer.pdf

Pages: 143

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